[{"_1":2,"_113":-5,"_114":-5},"loaderData",{"_3":4,"_9":10},"root",{"_5":6,"_7":8},"locale","id","isCms",false,"routes/tags/$slug",{"_11":12,"_13":14,"_15":16,"_100":101,"_107":103,"_111":106,"_112":-5},"slug","kelenjar-getah-bening","ads",[],"posts",[17],{"_6":18,"_19":20,"_11":21,"_22":23,"_24":25,"_26":27,"_28":29,"_30":31,"_32":33,"_34":35,"_36":37,"_38":39,"_40":41,"_42":43,"_44":45,"_46":47,"_48":49,"_50":51,"_52":53,"_54":55,"_56":57,"_58":59,"_60":61,"_97":98,"_70":99},"019bb788-df7f-713d-8c83-7310bd8e929f","title","Peneliti China gunakan kelenjar getah bening yang dikeringkan beku untuk pengobatan tumor","sel-t-reseptor-antigen-kimerik-chimeric-antigen-receptor-car","main_id","019bb73f-297b-7103-96b7-87ea173dc182","main_name","Iptek","main_slug","iptek-id","date","2024-03-23 10:57:46","author_id","019bb745-b426-73a2-9a49-5ddcb6765ea0","author_name","indowin","full_name","Indonesia Window","author_firstname","Indonesia","author_slug","indonesiawindow","content","

Sel T reseptor antigen kimerik (chimeric antigen receptor/CAR) yang dapat secara akurat mengidentifikasi dan menghilangkan sel tumor pada titik-titik tertentu telah disintesis dan digunakan dalam pengobatan klinis tumor hematologis.

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Hangzhou, China (Xinhua) – Sebuah tim peneliti China menggunakan kelenjar getah bening yang dikeringkan beku untuk meningkatkan efek kuratif obat-obat antitumor, ungkap Universitas Zhejiang.

Dalam beberapa tahun terakhir, obat sel menjadi makin penting sebagai terapi yang menargetkan tumor. Sel T reseptor antigen kimerik (chimeric antigen receptor/CAR) yang dapat secara akurat mengidentifikasi dan menghilangkan sel tumor pada titik-titik tertentu telah disintesis dan digunakan dalam pengobatan klinis tumor hematologis.

Namun demikian, kendala ditemukan untuk membuat sel T CAR memainkan peran yang bertahan lama dan efisien di titik tumor padat.

Para peneliti dari Fakultas Ilmu Farmasi Universitas Zhejiang dan Rumah Sakit Afiliasi Pertama Fakultas Kedokteran Universitas Zhejiang mengemukakan gagasan untuk memasukkan sel T CAR ke kelenjar getah bening, yang sering diangkat saat operasi tumor.

Mereka menggunakan teknologi pengeringan beku (freeze-drying) untuk secara efektif menjaga struktur berpori dan bahan aktif kelenjar getah bening, kemudian menggunakannya sebagai medium untuk menyimpan dan memberikan obat sel antitumor, sehingga pengobatan menjadi lebih manjur dan tahan lama.

Tim peneliti tersebut telah melakukan verifikasi melalui model hewan bahwa teknik baru ini dapat secara efektif menghambat kambuhnya tumor pascaoperasi, kata Gu Zhen dari Fakultas Ilmu Farmasi Universitas Zhejiang, salah satu peneliti.

Penelitian ini telah dipublikasikan di jurnal Nature Materials.

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