[{"_1":2,"_118":-5,"_119":-5},"loaderData",{"_3":4,"_9":10},"root",{"_5":6,"_7":8},"locale","id","isCms",false,"routes/tags/$slug",{"_11":12,"_13":14,"_15":16,"_105":106,"_112":108,"_116":111,"_117":-5},"slug","sel-kanker","ads",[],"posts",[17],{"_6":18,"_19":20,"_11":21,"_22":23,"_24":25,"_26":27,"_28":29,"_30":31,"_32":33,"_34":35,"_36":37,"_38":39,"_40":41,"_42":43,"_44":45,"_46":47,"_48":49,"_50":51,"_52":53,"_54":55,"_56":57,"_58":59,"_60":61,"_102":103,"_70":104},"019be5f1-7fc4-72fe-b1cc-b058e257fe57","title","Studi: Sel kanker dapat merusak DNA sendiri saat tumbuh, berpotensi jadi target terapi","studi:-sel-kanker-dapat-merusak-dna-sendiri-saat-tumbuh,-berpotensi-jadi-target-terapi","main_id","019bb73f-297b-7103-96b7-87ea173dc182","main_name","Iptek","main_slug","iptek-id","date","2026-01-22 00:00:00","author_id","019bb745-b426-73a2-9a49-5ddcb6765ea0","author_name","indowin","full_name","Indonesia Window","author_firstname","Indonesia","author_slug","indonesiawindow","content","

Sel kanker dapat merusak DNA-nya sendiri melalui proses yang sama yang mendorong pertumbuhan agresifnya, mengungkap kerentanan utama yang dapat dimanfaatkan untuk pengobatan baru.

Yerusalem, Wilayah Palestina yang diduduki (Xinhua/Indonesia Window) – Para peneliti Israel menemukan bahwa sel kanker dapat merusak DNA-nya sendiri melalui proses yang sama yang mendorong pertumbuhan agresifnya, mengungkap kerentanan utama yang dapat dimanfaatkan untuk pengobatan baru, demikian menurut pernyataan Universitas Ibrani Yerusalem pada Rabu (21/1).

Studi itu, yang dipublikasikan dalam jurnal Science Advances, menunjukkan bahwa pengatur genetik hiperaktif yang disebut \"super-enhancer\" memaksa gen kanker untuk bekerja pada kecepatan maksimum. Namun, \"super-enhancer\" ini juga menciptakan \"tekanan\" yang sangat besar pada DNA dan dapat menyebabkan patahan (break).

Menggunakan pemetaan canggih, para peneliti menemukan bahwa patahan-patahan DNA ini terjadi berulang kali di sejumlah wilayah dengan aktivitas tinggi yang sama. Meski sel kanker mampu memperbaiki patahan-patahan tersebut, siklus patah dan perbaikan yang berulang dapat membuat wilayah-wilayah ini semakin rentan terhadap akumulasi mutasi seiring waktu.

\"Singkatnya, mekanisme yang sama yang membantu kanker tumbuh dengan cepat juga dapat membuat DNA-nya lebih rapuh,\" tambah pernyataan tersebut.

Temuan itu mengarah pada sebuah strategi pengobatan yang menjanjikan. Menargetkan wilayah-wilayah DNA yang mengalami stres berlebih ini akan dapat mengganggu siklus pertumbuhan kanker, memperlambat kemampuannya untuk berevolusi, dan membuat tumor lebih sensitif terhadap terapi yang ada, papar laporan tersebut.

Laporan: Redaksi

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